Parental investigations in RPL are an important step in identifying potential causes of recurrent pregnancy loss and can help couples make informed decisions about their options for fertility treatments.
Hormone testing can help identify any hormonal imbalances that may be contributing to RPL. Tests may include levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and progesterone.
Ultrasound can be used to evaluate the uterus and ovaries to identify any structural abnormalities that may be contributing to RPL. This may include abnormalities such as uterine fibroids, polyps, or a septum.
An endometrial biopsy involves removing a small sample of the uterine lining for examination under a microscope to identify any abnormalities in the endometrium that may be contributing to RPL.
Immunological testing may be conducted to identify any autoimmune disorders that may be contributing to RPL, such as antiphospholipid syndrome or lupus.
Thrombophilia testing may be conducted to identify any clotting disorders that may be contributing to RPL, such as Factor V Leiden or protein C or S deficiency.
Genetic testing may be conducted to identify any genetic abnormalities that may be contributing to RPL. This may include karyotyping for the couple.
Parental investigations in RPL typically involve chromosomal analysis of both parents to identify any structural or numerical chromosomal abnormalities. This can be done by karyotyping.
Karyotyping involves analyzing a sample of cells from each parent’s blood or other tissues to examine the chromosomes for any abnormalities such as missing or extra chromosomes, or rearrangements of chromosome segments