Help Line :
Find My Tests
Logo of Anderson clinical genetics designed in blue and orange combination.

PGT-M (PGD)

(Preimplantation Genetic Testing - Monogenic)
Inherited illnesses,
the stories of the past.

While PGT-A (PGS) helps in identifying embryos with normal chromosome counts, PGT-M (PGD) ensures that the selected embryos are free from any kind of inherited genetic disorders. PGT-M (PGD) is performed for the diagnosis of single gene disorders that can be passed on to the next generation. PGT-M (PGD) can aid in the identification of over 400 single gene disorders including Sickle cell anaemia, Cystic Fibrosis, Tay Sachs, Fragile X, Myotonic Dystrophy and Thalassemia.

When is PGT-A (PGS)
Recommended

The couples with a history of genetic disorders in their families should undergo PGT-M (PGD).

Fertile couples with a family history of single gene disorders can also opt for an IVF cycle coupled with PGT-M (PGD)

BENEFITS

PGT-M (PGD) enables examination of single gene mutations and individual carriers of diseases such as cystic fibrosis, sickle cell anaemia etc.

Test is customised based on the nature of genetic disorder often associated with patient’s family medical history. The genetic fingerprint of the mutation can be seen in the embryos (if any) so that the affected embryos can be avoided.

PGT-A (PGS) is always coupled with PGT-M (PGD), therefore chromosomal number variations are also tested.

PGT-M (PGD) can be applied to test for almost any genetic condition that has been diagnosed in the parents, where a specific gene is known to cause that condition.

PGT-M (PGD) Process

Flow chart explaining PGT-M (PGD) ProcessFlow chat the explains PGT-M (PGD) process from Assisted Reproduction (ART) to Genetically healthy baby.

How is PGT-M (PGD) performed?

STEP 1

Unlike PGT-A (PGS), PGT-M (PGD) is very much unique for each family. Given that, the to-be-parents know the genetic disorders run through their family and are ready to undergo several tests, as prescribed by your specialist.

STEP 2

A preliminary screening is performed on the parent’s blood to diagnose the genes responsible for the disease and their inheritance pattern.

STEP 3

The embryos are created using the traditional IVF method followed by your fertility specialist.

STEP 4

The embryologist will remove few cells from the embryos to proceed with the testing.

STEP 5

The unaffected embryos are identified and they will be populated in the uterus. This helps in giving birth to a disease-free baby.

For Whom?

Appropriate for people who are at high-risk of passing on single gene disorders such as Cystic Fibrosis, Muscular Dystrophies, autosomal dominant conditions, hereditary cancer syndrome, etc. Even if one among the parents is possessing any one of the above issues, PGT-M (PGD) becomes compulsory.

Benefits

Helps in detecting known genetic diseases and chromosomal abnormalities.

Prevents unhealthy embryos from being transferred into the uterus.

Reduces pregnancy risks and increases the chances of making IVF cycle a successful one.

Even the parents with inherited genetic disorders can produce healthy babies, free from any such issues.

Preimplantaion Genetic Diagnosis (PGT-M (PGD)) for Single Gene Disorders

  • Choleastasis, progressive familial intrahepatic
  • ACADM deficiency
  • Bardet-Biedl syndrome
  • Cystic fibrosis
  • Charcot-Marie-Tooth disease, typr 1 B
  • Stickler syndrome, type II
  • Osteogénesis imperfecta
  • Spondyloepiphyseal dysplasia
  • Muscular dystrophy-dystroglycanopathy
  • Multiple endocrine neoplasia II
  • Retinitis pigmentosa
  • Central core disease
  • Duchenne muscular dystrophy
  • Steinhert (DM1)
  • Jeune syndrome
  • Cerebral Vascular Disease
  • Exostoses, type I
  • Exostoses, type II
  • Hemophilia A
  • Hydrocephalus
  • Marfan syndrome
  • Fragile X syndrome
  • Spinal muscular atrophy
  • Spastic paraplegia AD type 3
  • Holt-Oram syndrome
  • Hemophagocytic lymphohistiocytosis, familial, 3
  • Mucopolysaccharidosis
  • Oculodentodigital dysplasia
  • Thalassemia-beta
  • Tay-Sachs disease
  • Histocompatibility
  • Lynch syndrome
  • Huntington disease
  • Combined immunodeficiency, X-linked
  • Amyotrophic lateral sclerosis (ALS)
  • Epidermolysis bullosa
  • Treacher Collins syndrome 1
  • Tuberous sclerosis-1
  • Saethre-Chotzen syndrome
  • Cardiomyopathy dilated
  • Renal cysts and diabetes syndrome
  • Multiple endocrine neoplasia
  • Ornithine transcarbamylase deficiency
  • Autosomal dominant Polycystic kidney disease 1
  • Autosomal dominant Polycystic kidney disease 2
  • Autosomal recessive Polycystic kidney and Hepatic disease
  • Charcot-Marie-Tooth disease, type 1A and type 1E
  • FSHD
  • CADASIL
No. 150, Poonamallee High Road,
(Opp to Dasaprakash Hotel)
Chennai – 600 084.
PURASAIWALKKAM CENTRE
Anderson Diagnostics and Labs, No. 150, Poonamallee High Road,
(Opp to Dasaprakash Hotel)
Chennai – 600 084.
TAMBARAM CENTRE
Anderson Diagnostics and Labs,
25,Elumalai street,
West Tambaram,
Chennai – 600 045
Mobile : 91766 03435
Anderson Diagnostics and Labs,
B.O. : 72A, East 4th Street,
K.K. Nagar, Madurai – 625020
Mobile : 9176677610
78239 77868
Chromepet
Old No 30 / New No : 4
Ramaswamy Street,
Radha Nagar,Chromepet
Chennai – 600044
Contact: 9176677861
Mylapore
ri SRN Neuro Clinic
No. 57/109, Ground Floor,
Ramakrishna Mutt Rd,
Mandaveli, Chennai – 600028
Contact: 9176604345
(Mylapore center is moved to above center)
Nanganallure
No-7, 36th Street, Thillaiganga Nagar, Nanganallure, Chennai – 600061 (Near to Thillaiganga Nagar Sub way)
Contact: 9962595022
Anna Nagar
No F-22, 2nd Main Road, Near Anna Nagar Metro Station, Anna Nagar East, Chennai – 600102,
Keelpakkam
No.26, Rajarathinam street,
Kilpauk,
Chennai - 600 010.
Contact: 99620 00048
No 29/8, 1st floor, Nassiyas Plaza,
Anna Salai,Near BSNL,
Vannarpettai,Tirunelveli,
Tamil Nadu 627003
No. 31C/B (Upstairs), Distillery road,
Opp to State Bank Road,
Nagercoil – 629 001
Contact: 9176733377
Bangalore
Anderson Diagnostic Services Pvt Ltd,
S A Heights (#8 4th cross), 7th block, Jayanagar, Bangalore, Karnataka - 560070.
Contact: 080-29900394
Nellore
D. No. 16-4-101,
DNR building,
2nd floor,
2nd Main Road,
Opp AIMS Hospital,
Pogathota,
Nellore – 524001
Contact: 7824898489
Mobile: 7824817604
Tirupati
22-8-149/B,
Sreenilayam complex,
8th Cross,
Upadyayanagar,
Tirupati.
Mobile: 7824898497
Landline:
8772970266
Mumbai
C Wing, Shop No :40, 2nd Floor,
Tardeo AC Market,
Tardeo Road,
Mumbai Central,
Mumbai - 400034.
Contact: 022-40055344
Anderson Clinical Genetics,
No. 401, Katuru Nivas, Srinagar colony, Hyderabad.
Contact: 8939088332
© 2023 Anderson Diagnostics & Labs. All rights are reserved.
Top magnifiercrossmenu linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram