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(Preimplantation Genetic  Testing - Aneuploidy)
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PGT-A (PGS): Improving Pregnancy Success Rates

Normal embryos carry 23 pairs of chromosomes. An imbalance in chromosome numbers, i.e. the presence of extra or missing chromosomes, has been implicated to be among the most common causes of implantation failure or miscarriages. Embryos carrying abnormal chromosome numbers occur frequently in infertile couples. Preimplantation Genetic Testing ( PGT-A (PGS)) is a genetic test performed on embryos to determine if the embryo is carrying a normal number of chromosomes. The chromosomal abnormal embryos are screened so as to select and transfer genetically healthy embryos. This increases the chances of attaining a healthy pregnancy and reduces the risk of miscarriages.
Image illustrating miscarriages due to an imbalance in chromosomes.
Vector image showing PGT-A (PGS) testing in the laboratory.

When is PGT-A (PGS) Recommended

  • Patients undergoing the IVF process can opt for PGT-A (PGS). In fact, chromosome screening is an add-on, as about 50% of IVF - derived embryos are known to carry chromosome abnormalities.
  • Studies suggest that women with advanced age and repeated implantation failure are at a higher risk of producing chromosomally abnormal embryos.
  • PGT-A (PGS) is also recommended for patients diagnosed with male factor infertility, specifically when sperm samples are reported to carry abnormal chromosome numbers
  • PGT-A (PGS) is recommended for Idiopathic infertility (cases where doctors are unable to conclude any apparent reason for infertility), several miscarriages, or failed IVF attempts.

PGT-A (PGS) Process

PGT-A (PGS) process involves removing a few cells from the developing embryo and testing them to determine if the embryo has the correct number of chromosomes. By selecting and transferring embryos with the correct number of chromosomes, PGT-A can improve the chances of a successful pregnancy.

Image showing the PGT-A (PGS) process in In Vitro Fertilization.A mobile view image showing the PGT-A (PGS) process in In Vitro Fertilization
PGT-A (PGS) Services
  • Genetic counselling on the probability of developing or transmitting chromosomal abnormalities in embryos
  • EMBRYO BIOPSY Day 5 - Frozen Embryo Transfer
  • Embryo Biopsy followed by NGS-based PGT-A (PGS) for aneuploidy of all 22 pairs of chromosomes
  • Accurate, reproducible, and rapid testing by Next Generation Sequencing (NGS)
Vector image showing the PGT-A (PGS) analysis for aneuploidy.
Vector image of a couple planning for a Pre-implantation Genetic Testing for Aneuploidy.
  • 15 Hours of automated NGS Protocol
  • Embryo biopsy assistance and validation
  • Wholly owned cold chain logistics
  • Planned elective single embryo transfer (SET)
  • Can be combined with PGT-M (PGD) cycle
Benefits of PGT-A

Preimplantation Genetic Testing for Aneuploidy (PGT-A) can provide several benefits for couples undergoing IVF treatment. Here are some of the advantages of using PGT-A to select genetically healthy embryos for transfer:

PGT-A (PGS) reduces miscarriage rates as only chromosomally normal embryos are selected for transfer
Can reduce the time to pregnancy
The embryos can be transferred with utmost confidence as the genetically healthy embryos have been selected
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