(Preimplantation Genetic Testing - Aneuploidy)

PGT-A (PGS): Improving Pregnancy Success Rates

Normal embryos carry 23 pairs of chromosomes. An imbalance in chromosome numbers, i.e. the presence of extra or missing chromosomes, has been implicated to be among the most common causes of implantation failure or miscarriages. Embryos carrying abnormal chromosome numbers occur frequently in infertile couples. Preimplantation Genetic Testing ( PGT-A (PGS)) is a genetic test performed on embryos to determine if the embryo is carrying a normal number of chromosomes. The chromosomal abnormal embryos are screened so as to select and transfer genetically healthy embryos. This increases the chances of attaining a healthy pregnancy and reduces the risk of miscarriages.

Image illustrating miscarriages due to an imbalance in chromosomes.

Vector image showing PGT-A (PGS) testing in the laboratory.

When is PGT-A (PGS) Recommended

Patients undergoing the IVF process can opt for PGT-A (PGS). In fact, chromosome screening is an add-on, as about 50% of IVF derived embryos are known to carry chromosome abnormalities.
Studies suggest that women with advanced age and repeated implantation failure are at a higher risk of producing chromosomally abnormal embryos.
PGT-A (PGS) is also recommended for patients diagnosed with male factor infertility, specifically when sperm samples are reported to carry abnormal chromosome numbers
PGT-A (PGS) is recommended for Idiopathic infertility (cases where doctors are unable to conclude any apparent reason for infertility), several miscarriages or failed IVF attempts.

PGT-A (PGS) Process

PGT-A (PGS) process involves removing a few cells from the developing embryo and testing them to determine if the embryo has the correct number of chromosomes. By selecting and transferring embryos with the correct number of chromosomes, PGT-A can improve the chances of a successful pregnancy.

A mobile view image showing the PGT-A (PGS) process in In Vitro Fertilization

PGT-A (PGS) Services

Genetic counselling on the probability of developing or transmitting chromosomal abnormalities in embryos
EMBRYO BIOPSY Day 5 - Frozen Embryo Transfer
Embryo Biopsy followed by NGS-based PGT-A (PGS) for aneuploidy of all 22 pairs of chromosomes
Accurate, reproducible and rapid testing by Next Generation Sequencing (NGS)

Vector image showing the PGT-A (PGS) analysis for aneuploidy.

Vector image of a couple planning for a Pre-implantation Genetic Testing for Aneuploidy.

15 Hours automated NGS Protocol
Embryo biopsy assistance and validation
Wholly owned cold chain logistics
Planned elective single embryo transfer (SET)
Can be combined with PGT-M (PGD) cycle

Benefits of PGT-A

Preimplantation Genetic Testing for Aneuploidy (PGT-A) can provide several benefits for couples undergoing IVF treatment. Here are some of the advantages of using PGT-A to select genetically healthy embryos for transfer:

PGT-A (PGS) reduces miscarriage rates as only chromosomally normal embryos are selected for transfer

Can reduce the time to pregnancy

The embryos can be transferred with utmost confidence as the genetically healthy embryos have been selected