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Oncomine Focus Assay
Single Panel for Testing 18 Types of Solid Tumors
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Sample Type
FFPE Block or Fresh Tissue in ONCO-Bank
TAT
2 to 3 weeks

Oncomine focus

  • Hot spot screening of relevant, druggable mutations, copy number changes and fusions for various Cancers
  • Analysing of 1000 variants across 52 genes for -- cancers
  • ACMG/AMP guidelines-based reporting with drugs and target information
  • NGS based assay eliminate need of multiple technology FISH, IHC, Realtime
  • High Sensitivity and Specificity
  • Identifies druggable targets in various cancers and unknown primary

Workflow

List of genes

SNV’s; Indels AKT1, ALK, AR, BRAF, CDK4, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ESR1, FGFR2, FGFR3, GNA11, GNAQ, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KIT, KRAS, MAP2K1, MAP2K2, MET, MTOR, NRAS, PDGFRA, PIK3CA, RAF1, RET, ROS1, SMO
CNV’s AKT1, ALK, AR, BRAF, CCND1, CDK4, CDK6, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, FGFR4, KIT, KRAS, MET, MYC, MYCN, PDGFRA, PIK3CA
Fusions ABL1, AKT3, ALK, AXL, BRAF, EGFR, ERBB2, ERG, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK2, NTRK3, PDGFRA, PPARG, RAF1, RET, ROS1
CENTRAL GENETIC LAB
Anderson Diagnostics and Labs,
No.26, Rajarathinam Street,
Kilpauk, Chennai - 600010.

SNV and CNV profile of oncomine focus genes in Pan-cancer data

All types of solid tumors showing the presence of mutation and copy number variation, in the genes present in oncomine focus assay. Hence, this assay best suited to identify druggable mutation, driver mutation or CNV changes and prognostic bio-markers.

Analyzed using: cbioportal.org.

Oncomine Fusion assay genes profile in Pan-cancer data

Multiple tumors such as Bone sarcoma, breast cancer, CRC, cholangiocarcinoma, gastric cancer, Head and neck cancer, melanoma, lung cancer, prostate cancer, salivary gland carcinoma, thyroid cancer, uterine sarcoma are showing fusion drivers in >2% of the cases, that can be detected by Oncomine focus assay.

Analyzed using: cbioportal.org.

Evidence based variant classification by Oncomine Reporter

Assay sensitivity and specificity

  • Can identify mutation with 5% variant allele frequency (5% mutant DNA, among 95% normal DNA).
  • LOD for RNA fusion is 255 copies of RNA.
  • RNA fusions and CNV changes detected by NGS has equal sensitivity to FISH.
  • Hence multiple testing is not required.

List of druggable targets

List of FDA approved drugs covered
Biomarker Drugs Disease
BRAF V600E; BRAF V600K Vemurafenib, Cobimetinib, Dabrafenib, Trametinib, Atezolizumab, Encorafenib Melanoma, NSCLC, CRC
ALK Fusion, EML4-ALK Crizotinib, Ceritinib, Alectinib, Brigatinib, Lorlatinib NSCLC
c-KIT Imatinib, Sunitinib, Regorafenib, Ripertinib GIST
EGFR Cetuximab, Mobocertinib, Afatinib, Gefitinib, Amivantamb, Osimertinib, Erlotinib Lung cancer
EGFR Panitumumab, Dacomitinib CRC
ERBB2 Fam-trastuzumab Deruxtecan-nxki NSCLC
ERBB2/HER2 amplification Trastuzumab, Pertuzumab, Ado-trastuzumab Emtansine Breast cancer, Gastric cancer
FGFR2-Fusions Pemigatinib, Infigratinib Cholangiocarcinoma
FGFR3 mutation/Fusion Erdafitinib Urothelial Cancer
KRAS Cetuximab, Panitumumab, Sotorasib CRC, NSCLC
NRAS Panitumumab CRC
MET, exon skipping Capmatinib NSCLC
NTRK1, NTRK2, NTRK3-fusions Larotrectinib, Entrectinib Pan solid tumors
PIK3CA Olaparib, Alpelisib Breast cancer, Pan solid tumors
RET-Fusions Pralsetinib, Selpercatinib NSCLC
RET-Fusions/mutation Selpercatinib Thyroid cancer
Ros1-fusions Entrectinib, Crizotinib NSCLC
Sample Type
FFPE Block or Fresh Tissue in ONCO-Bank
TAT
2 to 3 Weeks
PURASAIWALKKAM CENTRE
NUNGAMBAKKAM CENTRE
Central Pathology Lab
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Authorized Collection Points
Tamil Nadu
Karnataka
Andhra Pradesh
Maharashtra
Telengana

Nellore
D. No. 16-4-101,
DNR building, 2nd floor,
2nd Main Road, Opp AIMS Hospital,
Pogathota, Nellore – 524001
Contact: 7824898489
Mobile: 7824817604Get Directions

Tirupati
22-8-149/B,
Sreenilayam complex,
8th Cross, Upadyayanagar,
Tirupati.
Mobile: 7824898497
Landline: 8772970266Get Directions

Mumbai
C Wing, Shop No :40, 2nd Floor, Tardeo AC Market, Tardeo Road,
Mumbai Central,
Mumbai - 400034
Contact: 022 - 40055344 Get Directions

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