Advanced PGT-M HLA Typing for IVF Embryo Matching

PGT-M HLA typing, known as a saviour sibling test, supports IVF embryo selection by identifying embryos free of genetic disorders and transplant compatible.
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Understanding PGT-M HLA Typing

For families with a child suffering from severe blood disorders or immune deficiencies, such as Beta Thalassemia, Fanconi Anemia, or Sickle Cell Anemia ‑ a hematopoietic stem cell transplant from a matched sibling may offer a curative treatment option in many cases. At our advanced genetic testing center, PGT-M with HLA typing is performed as part of specialised Preimplantation Genetic Testing using Next-Generation Sequencing (NGS) technology. This allows parents to select an embryo that is not only unaffected by the family’s hereditary condition but is also a highly compatible tissue match for their sick child, significantly increasing the chances of a successful transplant.

Who Should Consider PGT-M HLA Typing?

This complex PGT-M HLA typing procedure is indicated for families who meet the following criteria:

Known Genetic Carriers

Parents who are carriers of a single-gene disorder (monogenic disease) that has already affected a living child.

Haematological Disorders

Families seeking a match for a sibling with thalassemia, leukemia, or diamond-blackfan anemia.

Primary Immunodeficiencies

Cases where a sibling requires a bone marrow or cord blood transplant to restore their immune system.

PGT-M HLA Typing Process

The process of HLA matched embryo selection requires a high level of technical precision and multidisciplinary coordination between our genetics lab and your IVF clinic:

Preliminary Feasibility Study

We begin by analysing the DNA of the parents and the affected child to develop a customised genetic test design based on haplotype analysis for the specific gene and HLA region.
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On Day 5 or 6 of the IVF cycle (Blastocyst stage) - a few cells are safely removed from the embryo.

Embryo Biopsy

Simultaneous Analysis

Our lab performs two tests on the same sample:

  • PGT-M: To confirm the embryo does not have the genetic disorder.
  • HLA Typing: To determine if the embryo’s tissue type matches the affected sibling.
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Prioritised Transfer

Through precise HLA matched embryo selection, only embryos that are both unaffected and HLA-matched are recommended for transfer - to support optimal clinical outcomes for both children and the family.
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A DNA Structure
An inquiry for a Male Reproductive Genetic Health testing appointment is illustrated.

Considering a Life-Changing Genetic Decision?

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Learn how advanced PGT-M HLA typing can help support critical treatment decisions for your child and family.
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Benefits of PGT-M HLA Typing

This dual-purpose screening supports improved transplant success while helping ensure the health of the future child.

High Compatibility Success
Selecting a matched sibling donor through HLA typing offers higher transplant success rates compared to unrelated donors in many clinical settings.
Eliminating Disease Transmission
PGT-M ensures that the new baby will not suffer from the same genetic condition as their sibling.
Reduced Risk of GVHD
Stem cell transplants from an HLA-identical sibling have a much lower risk of Graft-versus-Host Disease (GVHD).